Image:DBA model.jpg

The DBA model for a polar RTP-Ter complex, indicating the notation used to specify the various dissociation equilibrium constants of the important reactions. Note that whereas the model shows that RTP binds as a dimer, it does not specify that RTP monomers cannot assemble cooperatively on the DNA in forming each dimer-DNA complex (see “Discussion”). In addition, the model does not specify the structural mechanism giving rise to cooperativity; this could be mediated through direct protein-protein interactions or by mechanisms associated with DNA structural changes. Source: Duggin et al. (2005)